Download e-book for iPad: A Short History of the Drug Receptor Concept (Science, by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis

By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell

ISBN-10: 0230554156

ISBN-13: 9780230554153

The receptor inspiration used to be essentially the most influential principles in 20th-century drugs since it might account for the hugely particular results of substances at the physique. This ebook is the 1st to supply an old dialogue of its starting place, improvement, gradual recognition into pharmacology and next effect on glossy medication. It additionally considers the social context that prompted the drug receptor's development., creating a helpful contribution to the background and knowing of recent medication.

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Extra info for A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History)

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In this chapter we discuss how Langley developed, over a period of 30 years and in diverse research contexts, his ideas on the mode of action of drugs and physiological substances on tissues and cells. 1 We will also consider the influence of other British and Continental European scientists on Langley’s thought and experimentation, and how his research themes were linked to other work in the Cambridge physiological laboratory and to the development of his academic career. By the late nineteenth century animal experimentation had developed into the key method of physiology.

This stood in sharp contrast to his own ‘pluralistic conception’ (plurimistische Anschauung), which was grounded in the idea of many receptors and a variety of different options to bind substances, depending on the kind of receptors and on the condition of the cells and tissues. 104 Ehrlich identified one opposing group of scientists at the Pasteur Institute in Paris. This bacteriological institute had been founded in 1888 as ‘a living memorial’ to Pasteur and stood in keen competition with Koch’s Institute for Infectious Diseases.

These trials on methylene blue were performed on prisoners of the Moabit Royal Prison (Königliche Strafanstalt Moabit) and the connected Observation Unit for Insane Criminals (Beobachtungsanstalt für geisteskranke Verbrecher). 57 In 1891, Robert Koch offered Ehrlich a laboratory of his own in the newly founded Institute for Infectious Diseases (Institut für Infektionskrankheiten). This was an important career step for Ehrlich, since Koch’s institute was one ‘of the most prestigious’ of the bacteriological institutes founded in Europe around this time.

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A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell


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